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Furosemide

5月 13th, 2024 News

Frusemide structural formula

Structural formula

Business number 016C
Molecular formula C12H11ClN2O5S
Molecular weight 330.74
label

furosemide,

Diuretic,

furaniline,

sulfonamide,

Abdominal acidity,

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid,

5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

Numbering system

CAS number:54-31-9

MDL number:MFCD00010549

EINECS number:200-203-6

RTECS number:CB2625000

BRN number:None

PubChem number:24277714

Physical property data

1. Character:White or off-white crystalline powder, odorless, almost tasteless.


2. Density (g/mL,25/4?): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC): 206


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturated vapor pressure (kPa,60ºC): Undetermined


13. Heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil and water (octanol/Log value of partition coefficient for water: undetermined


17. Explosion limit (%,V/V): Undetermined


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility:Soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water

Toxicological data

None

Ecological data

None

Molecular structure data


1. Molar refractive index: 75.76


2. Molar volume (m3/mol ): 205.8


3. isotonic specific volume (90.2K):606.2


4. Surface Tension (dyne/cm):75.2


5. Polarizability?10-24cm3):30.03


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 7

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 4

6. Topological molecule polar surface area 131

7. Number of heavy atoms: 21

8. Surface charge: 0

9. Complexity: 481

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dry place.

Synthesis method

From 2, 4-dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-Sulfamoyl benzoic acid is then condensed with furfurylamine to produce furosemide.

Purpose

This product has a strong but short-lived diuretic effect. It is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.

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1,2-Dibromo-3-chloropropane

5月 13th, 2024 News

1,2-dibromo-3-chloropropane structural formula

Structural formula

Business number 02AG
Molecular formula C3H5Br2Cl
Molecular weight 236.33
label

Dibromochloropropane,

3-Chloro-1,2-dibromopropane,

Fumazone,

Nemagon,

Nemazont,

Dibromochloropropane,

soil fumigant,

nematicides,

Halogenated hydrocarbon solvents

Numbering system

CAS number:96-12-8

MDL number:MFCD00039365

EINECS number:202-479-3

RTECS number:TX8750000

BRN number:1732077

PubChem number:24862844

Physical property data

1. Properties: light yellow liquid with pungent odor.

2. Relative density (g/mL, 20/4?): 2.081

3. Relative vapor density (g/mL, air=1): 8.2

4. Melting point (ºC): 6

5. Boiling point (ºC, normal pressure): 200

6. Boiling point (ºC, 1.33KPa): 196

7. Refractive index (25ºC): 1.553

8. Flash point (ºC): 77

9. Saturated vapor pressure (kPa, 21ºC): 0.12

p>

10. Solubility: Slightly soluble in water, soluble in ethanol, acetone, hydrocarbons, etc. Miscible with oils, dichloropropane and isopropyl alcohol.

Toxicological data

1. Irritation: Rabbit transdermal: 10 g severe irritation. Rabbit eye: 1% mild irritation.

2. Acute toxicity: Oral LD5O in rats: 170mg/kg

Oral LD5O in mice: 260mg/kg

Inhalation LC50 in rats: 154ppm, 4 hours 3. Harmful to human body. It is highly toxic and has been found to be carcinogenic in oral tests on mice.

Ecological data

This substance is harmful to the environment. Special attention should be paid to the pollution of water and air. It is extremely destructive to the atmospheric ozone layer.

Molecular structure data

1. Molar refractive index: 36.21

2. Molar volume (cm3/mol): 116.1

3. Isotonic specific volume (90.2K ): 291.6

4. Surface tension (dyne/cm): 39.6

5. Dielectric constant:

6. Dipole moment (10-24cm3):

7. Polarizability: 14.35

Compute chemical data

1. Hydrophobic parameter calculation reference value (XlogP): 2.4

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 0

4. Number of rotatable chemical bonds: 2

p>

5. Number of tautomers:

6. Topological molecular polar surface area (TPSA): 0

7. Number of heavy atoms: 6

8. Surface charge: 0

9. Complexity: 32

10. Number of isotope atoms: 0

11. Determine the atomic configuration Number of centers: 0

12. Uncertain number of atomic stereocenters: 1

13. Determined number of chemical bond stereocenters: 0

14. Uncertain Number of stereocenters of chemical bonds: 0

15, number of covalent bond units: 1

Properties and stability

Avoid contact with strong oxidizing agents.

Storage method

Store in a cool, ventilated warehouse. Keep away from fire and heat sources. They should be stored separately from oxidants and food chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with emergency release equipment and suitable containment materials.

Synthesis method

Add 3-chloropropene and bromine at normal pressure and 10-25°C, and the reaction product is purified by vacuum distillation. Add the original drug to the emulsifier and xylene, and emulsify at 55-60°C for half an hour to make an 80% emulsion. Raw material consumption quota: 3-chloropropene (92%) 310kg/t, liquid bromine 600kg/t

Purpose

Mainly used as solvent, soil fumigant, and nematicide.

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sodium salicylate

5月 13th, 2024 News

Sodium salicylate structural formula

Structural formula

Business number 016A
Molecular formula C7H5NaO3
Molecular weight 160.1
label

Sodium o-hydroxybenzoate,

2-Hydroxybenzoic acid monosodium salt,

sodium salicylate,

Sodium Cylate,

Sodium 2-Hydroxybenzoate,

2-Hydroxybenzoic acid sodium salt,

Salicylic acid sodium salt,

preservative

Numbering system

CAS number:54-21-7

MDL number:MFCD00002440

EINECS number:200-198-0

RTECS number:VO5075000

BRN number:3732792

PubChem number:24899540

Physical property data

1. Properties: White scaly crystals or powder. Odorless. It turns pink when exposed to light.

2. Density (g/mL, 25/4?): Undetermined

3. Relative vapor density (g/mL, air=1): Undetermined

4. Melting point (ºC): 160?166

5. Boiling point (ºC, normal pressure): Undetermined

6. Boiling point (ºC, 5.2kPa): Undetermined

7. Refractive index: Undetermined

8. Flash point (ºC): Undetermined

9. Specific rotation (º): Undetermined Determined

10. Autoignition point or ignition temperature (ºC): Not determined

11. Vapor pressure (kPa, 25ºC): Not determined

12. Saturated vapor pressure (kPa, 60ºC): Undetermined

13. Heat of combustion (KJ/mol): Undetermined

14. Critical temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Log value of oil-water (octanol/water) partition coefficient: Undetermined

17. Explosion upper limit ( %, V/V): Undetermined

18. Lower explosion limit (%, V/V): Undetermined

19. Solubility: Easily soluble in water, ethanol, and glycerin. Almost insoluble in ether, chloroform and benzene. 1g product is dissolved in 0.9ml water, 9.2ml ethanol and 4ml glycerol. The aqueous solution is slightly acidic, with a pH of 5 to 6.

Toxicological data

Ecological data

None

Molecular structure data

None

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: 4

6. Topological molecule polar surface area 60.4

7. Number of heavy atoms: 11

8. Surface charge: 0

9. Complexity: 138

10. Number of isotope atoms: 0

11. Determine the atomic stereocenter Quantity: 0

12. Uncertain number of stereocenters of atoms: 0

13. Determined number of stereocenters of chemical bonds: 0

14. Uncertain chemical bonds Number of stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

1. Turns pink when exposed to light.

Storage method

Keep away from light.

Synthesis method

1. Add salicylic acid and sodium bicarbonate alternately into distilled water, keep the temperature at 60°C, and keep it in an acidic state. At the same time, add an appropriate amount of ethylenediaminetetraacetic acid (EDTA) and insurance powder. Raise the temperature to 85°C and react for half an hour. The qualified reaction liquid is filtered and sent to the ebullating bed, and dried at 85°C to obtain salicylic acid.

2.Dissolve salicylic acid in distilled water at 50°C, and slowly neutralize it with dilute sodium hydroxide to pH while stirring. Value 5.4~5.8:

After the reaction, decolorize and filter. After the filtrate is clear, concentrate it under reduced pressure to a slurry, cool it, filter out the crystals, and dry it to get the finished product.

Purpose

1. Organic synthetic raw materials, preservatives, and reagents for measuring free acid in gastric juice. Antipyretics, analgesics and antirheumatic drugs. 2. Used as analytical reagent. Also used in organic synthesis, medicine, electronics, instrumentation, metallurgical industry, etc.

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