thalidomide

thalidomide

Thalidomide structural formula

Structural formula

Business number 013L
Molecular formula C13H10N2O4
Molecular weight 258.23
label

Mabofloxacin,

Marbofloxacin,

thalidomide,

Phantamidone,

N-(2,6-dioxo-3-piperidinyl)-phthalimide,

(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione,

Zeniquine,

sedative

Numbering system

CAS number:50-35-1

MDL number:MFCD00153873

EINECS number:200-031-1

RTECS number:TI4375000

BRN number:None

PubChem number:24278765

Physical property data

1. Properties: light yellow crystalline powder, odorless, tasteless

2. Density (g/mL, 25/4?): Undetermined

3. Relative Vapor density (g/mL, air=1): Undetermined

4. Melting point (ºC): 269-271°C

5. Boiling point (ºC, normal pressure): Undetermined

6. Boiling point (ºC, 5.2 kPa): Undetermined

7. Refractive index: Undetermined

8. Flash point (ºC): Undetermined

9. Specific rotation (º): Undetermined

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa, 25 ºC): Not determined

12. Saturated vapor pressure (kPa, 60 ºC): Not determined

13. Heat of combustion (KJ/mol): Not determined Determined

14. Critical temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Oil and water (octanol/water ) Log value of distribution coefficient: Undetermined

17. Explosion upper limit (%, V/V): Undetermined

18. Explosion lower limit (%, V/V): Undetermined Confirm

19. Solubility: Slightly soluble in water (<0.1 g/100 mL at 22 ºC), ethanol, acetone, insoluble in ether and chloroform. 45% (w/v) aq 2-hydroxypropyl-?-cyclodextrin: 0.6 mg/mL

Toxicological data

None

Ecological data

None

Molecular structure data

1. Molar refractive index: 62.35

2. Molar volume (cm3/mol): 171.7

3. Isotonic specific volume (90.2K ): 496.5

4. Surface tension (dyne/cm): 69.9

5. Polarizability (10-24cm3): 24.71

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: 8

6. Topological molecule polar surface area 83.6

7. Number of heavy atoms: 19

8. Surface charge: 0

9. Complexity: 449

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 1

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a dry place away from light.

Synthesis method

None

Purpose

It has a certain effect on various types of leprosy reactions, such as fever, nodular erythema, neuralgia, joint pain, lymphadenopathy, etc., but has a slightly less effective effect on tuberculosis-like leprosy reactions. It has no therapeutic effect on leprosy and can be used together with anti-leprosy drugs to reduce reactions. The preparation is a tablet. This product has strong teratogenic effects and is contraindicated in pregnancy. This medicine should not be used by people without leprosy. Side effects include dry mouth, dizziness, nausea, abdominal pain, etc.

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propantheline bromide

propantheline bromide

Propantheline bromide structural formula

Structural formula

Business number 013K
Molecular formula C23H30NO3Br
Molecular weight 448.4
label

propantheline bromide,

Prubenzin,

Propanthyl bromide,

(2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate

Numbering system

CAS number:50-34-0

MDL number:MFCD00050291

EINECS number:200-030-6

RTECS number:BP8249200

BRN number:None

PubChem number:24278660

Physical property data

1. Character:White or off-white crystalline powder. Odorless and extremely bitter.


2. Density (g/mL ,25/4?): Undetermined


3. Relative vapor density (g/mL,air=1): Undetermined


4. Melting point (ºC):159-161°C


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC, 5.2 kPa): Undetermined


7. Refractive index:Undetermined


8. Flash point (ºC): Undetermined


9. Specific optical rotation (º ): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa, 25 ºC): Undetermined


12. Saturated vapor pressure (kPa,60 ºC): Undetermined


13. Heat of combustion (KJ/ mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil and water (octanol/ Log value of partition coefficient for water: undetermined


17. Explosion limit (%,V/V): Undetermined


18. Lower explosion limit (%, V/V): Undetermined


19. Solubility:Easily soluble in water(>=10 g/100 mL at 21 ºC), ethanol or chloroform, insoluble In ether.


Toxicological data

None

Ecological data

None

Molecular structure data

None

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 7

5. Number of tautomers: none

6. Topological molecule polar surface area 35.5

7. Number of heavy atoms: 28

8. Surface charge: 0

9. Complexity: 474

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

None

Storage method

This product is sealed and stored in a dry place away from light.

Synthesis method

Xanton-9-Carboxylic acid and diisopropylaminoethanol ester in xylene??, on137-140?Dehydration reaction10h. After the reaction is completed, add activated carbon for decolorization and cool to 0?, pressure filtration, and the filtrate is decompressed to recover xylene and excess Diisopropylaminoethanol, xanthene-9- Carboxylic acid-?-Diisopropylaminoethyl ester. Then react with methyl bromide to form a quaternary ammonium salt to prepare propantheline bromide.

Purpose

anticholinergic and antispasmodic, Has similar effects to atropine. It is suitable for gastric and duodenal ulcers, gastritis, pancreatitis, intestinal spasm, hyperhidrosis and pregnancy vomiting.

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phenylbutazone

phenylbutazone

Phenylbutazone Structural Formula

Structural formula

Business number 013J
Molecular formula C19H20N2O2
Molecular weight 308.38
label

phenylbutazone,

4-Butyl-1,2-diphenyl-3,5-pyrrolidinedione,

Butanone,

Butazolidine,

Buteqian,

Benzodizoline,

4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione,

Phenylbutazone

Numbering system

CAS number:50-33-9

MDL number:MFCD00005500

EINECS number:200-029-0

RTECS number:UQ8225000

BRN number:290080

PubChem number:24277729

Physical property data

1. Properties: white or off-white crystalline powder. Odorless, slightly bitter taste

2. Density (g/mL, 25/4?): Undetermined

3. Relative vapor density (g/mL, air=1) : Undetermined

4. Melting point (ºC): 104-107 °C

5. Boiling point (ºC, normal pressure): Undetermined

6. Boiling point (ºC, 5.2 kPa): Not determined

7. Refractive index: Not determined

8. Flash point (ºC): Not determined

9. Specific rotation (º): Undetermined

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa, 25 ºC): Undetermined

12. Saturated vapor pressure (kPa, 60 ºC): Undetermined

13. Heat of combustion (KJ/mol): Undetermined

14. Critical Temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Log value of oil-water (octanol/water) partition coefficient: Undetermined

p>

17. Explosion upper limit (%, V/V): Undetermined

18. Explosion lower limit (%, V/V): Undetermined

19. Dissolution Properties: Easily soluble in acetone, chloroform or benzene, soluble in ethanol or ether, almost insoluble in water (<0.1 g/100 mL at 23.5 ºC), soluble in sodium hydroxide solution

Toxicological data

None

Ecological data

None

Molecular structure data

1. Molar refractive index: 88.7

2. Molar volume (cm3/mol): 262.7

3. Isotonic specific volume (90.2K ): 689.4

4. Surface tension (dyne/cm): 47.3

5. Polarizability (10-24cm3): 35.16

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 2

6. Topological molecule polar surface area 40.6

7. Number of heavy atoms: 23

8. Surface charge: 0

9. Complexity: 389

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a dry place away from light.

Synthesis method

None

Purpose

Organic synthesis. medicine.

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