N-Formylmorpholine Safety Data Sheet

N-Formylmorpholine (N-Formylmorpholine), chemical formula C5H9NO, is a multifunctional organic compound widely used in chemical synthesis, Solvent and pharmaceutical industries. Due to its industrial importance, understanding its safety features is crucial to ensuring a safe workplace. The following is a summary of the N-Formylmorpholine Safety Data Sheet (SDS) based on general information covering its physical and chemical properties, health hazards, first aid measures, fire and explosion protection information, emergency release handling, handling and storage recommendations, and environmental protection measure.


1. Chemical identification

Product identification: N-formylmorpholine

Chemical name: N-Formylmorpholine

CAS number: [Fill in the actual CAS number here]

EINECS number: [Fill in the actual EINECS number here]

Molecular formula: C5H9NO

Molecular weight: about 101.13 g/mol

2. Risk Overview

Hazard Category:

  • Physical Hazards: Flammable liquids, vapors and air form explosive mixtures.
  • Health Hazards: May cause irritation and toxicity by inhalation, ingestion, or skin contact.
  • Environmental Hazard: Toxic to aquatic life.

Signal word: warning

Hazard Statement:

  • H225: Highly flammable liquid and vapor.
  • H315: Causes skin irritation.
  • H319: Causes serious eye irritation.
  • H335: May cause respiratory tract irritation.
  • H411: Toxic to aquatic life with long lasting effects.

Precautionary instructions:

  • P210: Keep away from heat, sparks, open flames and hot surfaces.
  • P261: Avoid breathing dust/fume/gas/mist/vapor/spray.
  • P273: Avoid release into the environment.
  • P305+P351+P338: If in eyes: Rinse carefully with water for several minutes. If you wear contact lenses and can easily remove them, remove them. Continue rinsing.

3. Composition/information components

  • Main ingredient: N-formylmorpholine
  • Purity/Concentration: [Fill in the actual purity/concentration here]
  • Other ingredients: [Fill in other additives or impurities here]

4. First aid measures

Inhalation:

  • Move to fresh air and keep breathing clear. If breathing is difficult, give oxygen. Seek medical attention.

Skin contact:

  • Take off contaminated clothing immediately and rinse skin with plenty of running water for at least 15 minutes. Seek medical attention.

Eye contact:

  • Immediately lift the eyelids and rinse thoroughly with running water or saline for 15 minutes. Seek medical attention.

Ingestion:

  • Do not induce vomiting. If swallowed, do not drink water unless directed by your doctor. Get medical attention immediately.

5. Firefighting measures

Fire-extinguishing media:

  • Use solvent-resistant foam, dry powder, or carbon dioxide to extinguish fires.

Special hazards:

  • Combustion produces toxic fumes, including carbon monoxide and nitrogen oxides.

6. Emergency leakage treatment

  • Wear appropriate personal protective equipment.
  • Isolate the leakage area and avoid direct contact.
  • Small spills: absorb with sand or other inert materials.
  • Substantial leakage: build dikes or dig pits to contain them.

7. Operation and storage

Operation precautions:

  • Operate in a well-ventilated area.
  • Avoid the generation of dust and vapors.
  • Use explosion-proof electrical equipment.

Storage Notes:

  • Store in a cool, dry and well-ventilated place.
  • Keep away from heat, sparks and open flames.
  • Store separately from oxidizing agents.

8. Exposure control/personal protection

Engineering Control:

  • Provide adequate local exhaust or general ventilation.

Respiratory protection:

  • Wear appropriate respiratory protective equipment when air pollutants exceed standards.

Eye protection:

  • Wear chemical safety glasses.

Body protection:

  • Wear protective clothing, gloves, and shoe covers.

9. Physical and chemical properties

  • Appearance and properties: Colorless to slightly yellow transparent liquid.
  • Melting point/freezing point: [Fill in actual melting point here]
  • Boiling point/boiling range: [Fill in actual boiling point here]
  • Flashpoint: [Fill in actual flashpoint here]
  • Explosion limit: [Fill in the actual explosion limit here]

10. Stability and reactivity

  • Avoid contact with strong oxidants, strong acids, and strong alkalis.

11. Toxicological information

  • Acute toxicity: LD50 (orally administered to mice) [fill in actual data here] mg/kg
  • Chronic toxicity: Long-term exposure may affect liver and kidney function.

12. Ecological information

  • Biodegradability: [Fill in actual data here]
  • Bioconcentration or bioaccumulation: [Fill in actual data here]

13. Disposal

  • Waste nature: [Fill in the actual waste nature here.??]
  • Waste disposal method: [Fill in the actual waste disposal method here]

14. Transportation information

  • United Nations number: [Fill in the actual UN number here]
  • Packaging category: [Fill in the actual packaging category here]

15. Regulatory information

  • Regulations: Comply with local and international chemical management regulations.

16. Other information

  • References: [List references here]

Please note that this SDS summary is based on general information. The actual safety data sheet should contain specific CAS number, EINECS number, purity , hazard classification and specific operating instructions. Always consult the complete safety data sheet and follow all applicable safety regulations before handling any chemical.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst

The role of N-formylmorpholine in pharmaceutical applications

N-Formylmorpholine (NFM), as a multifunctional organic compound, is not only used in the fields of industrial solvents and extraction agents It has a wide range of applications and plays an important role in the field of medicinal chemistry. Its chemical structure gives it unique advantages as an intermediate, reaction medium, and modifier. The following are some important roles of N-formylmorpholine in pharmaceutical applications:

1. Chemical intermediates

N-Formylmorpholine can be used as a key intermediate in the synthesis of various drugs. The chemical reactions it participates in can build complex molecular skeletons, especially when synthesizing drug molecules containing heterocyclic structures. For example, NFM can serve as a formylation reagent to introduce a formyl group, a common functional group in many bioactive molecules. The introduction of formyl groups can not only change the polarity and solubility of the drug, but may also enhance the biological activity or metabolic stability of the drug.

2. Reaction solvent

NFM, as a mild and stable solvent, can promote a variety of chemical reactions without destroying sensitive intermediates. Its use in organic synthesis reduces dependence on traditional toxic or unstable solvents and improves reaction selectivity and yield. Especially in multi-step synthesis processes, the use of N-formylmorpholine can simplify reaction conditions and reduce the formation of by-products, thus improving the overall synthesis efficiency and economy.

3. Improve the physical and chemical properties of drugs

By interacting with drug molecules, N-formylmorpholine can improve the solubility, stability and bioavailability of drugs. For example, by forming NFM derivatives, drug forms with better pharmacokinetic properties can be designed, which can help improve the absorption, distribution, metabolism, and excretion (ADME) properties of the drug.

4. Preparation of drug prodrugs

NFM is also used in the preparation of drug prodrugs, such as the preparation of specifically labeled compounds through reactions involving NFM for drug metabolism research or the development of radiopharmaceuticals. These labeled compounds can help researchers track the metabolic pathways of drugs in the body and evaluate the targeting and safety of drugs.

5. Development of drug delivery systems

NFM can also be used to develop new drug delivery systems. Due to its good solubility and compatibility with other substances, NFM can be used as part of the carrier material to encapsulate drugs to achieve sustained or targeted release, reduce drug side effects and improve therapeutic effects.

6. Antibacterial and antiseptic applications

N-Formylmorpholine has certain antibacterial properties and can be used as a preservative in certain pharmaceutical formulations to extend the validity period of pharmaceutical preparations. This is particularly important for drugs that require long-term storage, ensuring that the drug maintains its efficacy throughout its shelf life.

7. Research Tools

In the process of drug discovery and development, NFM is used as a research tool to screen and optimize drug candidate molecules. It helps chemists understand interactions between molecules, identify potential drug targets, and evaluate the pharmacological activity of compounds.

In summary, the role of N-formylmorpholine in pharmaceutical applications is multifaceted, from serving as a chemical intermediate and solvent, From improving the physicochemical properties of drugs to the development of drug delivery systems and preservatives, NFM has taken its place in modern medicinal chemistry. With the continuous deepening of scientific research, the potential application fields of NFM will be further expanded. However, it is worth noting that the use of NFM needs to strictly follow safety regulations. Considering its potential irritation and toxicity, it must be operated under professional guidance to protect the health and safety of laboratory personnel.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst

Detailed analysis of the physical and chemical properties of N-formylmorpholine

N-formylmorpholine (NFM), with the chemical formula C5H9NO, is a multifunctional organic compound with its unique Its physical and chemical properties have shown wide application potential in many fields such as chemistry, pharmaceuticals, agriculture, etc. This article will deeply explore the main physical and chemical properties of N-formylmorpholine, including its physical state, solubility, stability, reactivity, etc., aiming to provide scientific basis for the application of NFM in various fields.

1. Physical properties

N-Formylmorpholine usually appears as a colorless to light yellow transparent liquid at room temperature, with a slight special odor. Its density is about 1.03g/cm³, which is slightly heavier than water. This characteristic makes it exhibit excellent performance in the application of solvents and extractants. The boiling point of NFM is approximately 200°C. Its high boiling point feature allows it to maintain good stability under high temperature conditions and is suitable for chemical reactions or processes that require higher temperatures.

2. Solubility

N-Formylmorpholine is an excellent solvent capable of dissolving a wide variety of organic and inorganic compounds, including those that are not readily soluble in water or other conventional solvents. It is partially miscible with water, but prefers to form a miscible system with organic solvents, which gives it unique advantages as a solvent or reaction medium in the fields of organic synthesis, pharmaceutical preparation, and pesticide formulation. The solubility characteristics of NFM provide chemists with greater flexibility, facilitating complex chemical transformations and high-yield product synthesis.

3. Stability and reactivity

N-Formylmorpholine is relatively stable at room temperature and pressure and is not prone to self-decomposition. However, it may undergo hydrolysis reaction under strong acid, strong alkali or high temperature conditions to generate morpholine and formic acid. This property limits the application of NFM under extreme conditions, but under mild conditions, the stability of NFM makes it an ideal chemical intermediate and reaction medium. The reactivity of NFM is mainly reflected in its ability to be used as a formylation reagent, participating in chemical reactions such as esterification and acylation, and used to synthesize compounds containing formyl groups. This feature is particularly important in drug synthesis and materials science.

4. Chemical structure and functional groups

The chemical structure of NFM consists of a six-membered ring morpholine group and a formyl group. The nitrogen atom on the morpholine ring has a lone pair of electrons and can participate in nucleophilic reactions; while the formyl group provides an active carbonyl group, which is easy to carry out various types of chemical reactions such as addition and substitution. This unique structural combination endows NFM with versatility in chemical synthesis, allowing it to participate in a variety of chemical transformations as catalysts, reaction media, or starting materials.

5. Security considerations

Although N-formylmorpholine is widely used in industry and scientific research, it is irritating to the skin, eyes and respiratory tract, and long-term or high-concentration exposure may cause discomfort. Therefore, when using NFM, appropriate safety precautions should be taken, such as wearing protective glasses, gloves, and a respirator to avoid direct contact and inhalation. In addition, NFM should be stored away from heat sources, sparks and open flames to prevent its vapor from forming explosive mixtures with air to ensure the safety of the working environment.

6. Environmental Impact and Disposal

N-Formylmorpholine has certain toxicity to aquatic organisms, and improper discharge may have a negative impact on the environment. Therefore, during the use and disposal of NFM, environmental protection principles should be followed and appropriate wastewater treatment technologies and waste recycling procedures should be adopted to reduce pollution to the natural environment. Proper planning and implementation of NFM’s environmental management strategies are of great significance to promoting sustainable development and protecting ecosystems.

Conclusion

N-Formylmorpholine, as a multifunctional organic compound, has broad application prospects in chemical synthesis, pharmaceuticals, agriculture and other fields with its unique physical and chemical properties. An in-depth understanding of the physical state, solubility, stability, reactivity and safety considerations of NFM will not only help its wider application in existing fields, but also lay a solid foundation for exploring its potential in emerging technologies and green chemistry. Foundation. In the future, with the continuous advancement of science and technology, NFM’s contribution to promoting industrial innovation and environmental protection will become increasingly significant.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst