Use of N-formylmorpholine in pesticides

N-formylmorpholine (NFM), as an organic compound, has found its unique application in the field of agricultural chemistry value, especially in the formulation and functional enhancement of pesticides. The versatility of NFM makes it an indispensable ingredient in pesticide formulations. Below we will explore the specific applications of N-formylmorpholine in pesticides and the scientific principles behind it.

1. As a solvent and synergist in pesticide formulations

N-Formylmorpholine is widely used as a solvent in pesticide formulations due to its excellent solubility properties. It can dissolve a variety of pesticide active ingredients, including those that are difficult to dissolve in water or other conventional solvents, thereby improving pesticide formulation efficiency and product quality. In addition, NFM, as a synergist, can enhance the biological activity of pesticides and improve their adhesion and penetration ability on the surface of target crops, thereby improving the efficiency of pesticide use and control effects.

2. Improve the stability of pesticides

NFM helps improve the stability of pesticides, especially under complex environmental conditions. It can protect the active ingredients of pesticides from the effects of light, heat, oxidation and other factors, extend the shelf life of pesticides, and ensure activity during storage and transportation. This improved stability is critical to the pesticide industry as it is directly related to the reliability and cost-effectiveness of pesticides in practical applications.

3. As an intermediate for synthetic pesticides

In the process of pesticide synthesis, N-formylmorpholine can serve as a key chemical intermediate and participate in the construction of specific structural units of pesticide molecules. Through the participation of NFM, chemists can design and synthesize a series of new pesticide compounds with different biological activities. These compounds may have higher selectivity, lower ecological risks, and longer duration of action, thereby providing safer and more effective pest management solutions for agricultural production.

4. Promote bioavailability of pesticides

The addition of NFM can significantly improve the adhesion and permeability of pesticides on plant leaves, which means that more active ingredients can be absorbed by crops and reach target pests and diseases. This characteristic is extremely important for improving the bioavailability of pesticides, because only when a sufficient amount of pesticides reaches the pests and diseases can it effectively exert its control effect, while also reducing environmental pollution and resource waste caused by excessive spraying.

5. Used for pesticide residue detection

In the field of pesticide residue analysis, N-formylmorpholine is sometimes used as a solvent or derivatization reagent during sample processing. With the assistance of NFM, pesticide residues can be more efficiently extracted and purified from complex matrices, thereby achieving accurate determination of pesticide residues in food and the environment, ensuring food safety and ecological environment monitoring.

6. As a component of biopesticides

In recent years, biopesticides have received increasing attention due to their lower environmental impact and eco-friendliness. NFM is used as a carrier or auxiliary for active ingredients in some biopesticide formulas to help deliver biologically active substances such as beneficial microorganisms, enzymes, and natural toxins to achieve the purpose of controlling pests and diseases. This application method not only reduces the dependence on chemical pesticides, but also promotes the sustainable development of agriculture.

Conclusion

The application of N-formylmorpholine in pesticides demonstrates its role in improving pesticide efficacy, ensuring crop health and promoting agricultural sustainability. important role. However, although NFM has significant advantages in the field of pesticides, its use still needs to be cautious and its potential effects on the environment and human health should be fully considered. Therefore, the development and use of pesticides must comply with strict regulatory standards to ensure that while increasing agricultural yields, they do not cause irreversible damage to the ecological environment. With the advancement of agricultural science and technology and the increase in environmental awareness, we look forward to seeing more innovative and green pesticide solutions, and N-formylmorpholine will play an indispensable role in this process.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst

Production technology of N-formylmorpholine

N-formylmorpholine (NFM) is an important organic solvent and fine chemical raw material because of its good Due to its solubility, high boiling point and relatively low toxicity and corrosiveness, it is widely used in many industrial fields, such as aromatic hydrocarbon extraction, butene concentration, and natural gas desulfurization. The production process of NFM mainly involves the esterification reaction of morpholine and methyl formate as raw materials, usually in the presence of a catalyst. The following is a typical production process flow of N-formylmorpholine:

Raw material preparation:

  • Morpholine: A six-membered cyclic nitrogen-containing compound that serves as the amine component of the reaction.
  • Methyl formate: Methyl formate acts as an acylating agent and provides a formyl group.

Catalyst selection:

  • The choice of transesterification catalyst is crucial to the reaction efficiency. Commonly used catalysts include sodium alkoxide, potassium alkoxide, organotin, titanate and their compounds, such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, Sodium tert-butoxide, potassium tert-butoxide, dibutyltin oxide, dioctyltin oxide, butyl titanate, etc.

Reaction conditions:

  • Mass ratio: The mass ratio of morpholine and methyl formate is usually 1.30~1.74:1 to ensure sufficient acylation reaction.
  • Catalyst dosage: The amount of catalyst added is generally 0.5% to 5% of the total weight of raw materials to promote the transesterification reaction.
  • Reaction pressure: The reaction can be carried out in the range of normal pressure to 0.6Mpa.
  • Reaction temperature: The appropriate reaction temperature range is 30~120? to balance the reaction rate and the suppression of side reactions.
  • Reaction time: The reaction time is usually set between 2 and 6 hours to ensure the completeness of the reaction.

Separation and purification:

  • Batch separation process:
    • Separation and recovery of methyl formate: through distillation, the operating pressure is 0.1~0.2Mpa, the reactor temperature is controlled at 68~82°C, and the methyl formate fraction is collected at the top of the tower.
    • Separation and recovery of methanol: Change the distillation pressure to normal pressure, raise the reactor temperature to 68~130°C, and collect methanol at the top of the tower.
    • Separation and recovery of morpholine: the crude product is filtered to remove the catalyst, and then distilled under a vacuum of 0.09~0.099MPa, the reactor temperature is 130 ~155?, morpholine is collected at the top of the tower.
    • Obtaining N-formylmorpholine: Maintain the above vacuum degree, raise the reactor temperature to 155~165°C, and collect N-formylmorpholine from the top of the tower.
  • Continuous separation process:
    • Similar to intermittent separation, but the entire process is carried out in continuous flow equipment, including flash tanks, evaporators, light component towers and vacuum product towers, etc., to improve efficiency and reduce energy consumption.

Product quality:

  • The N-formylmorpholine produced should be a colorless and transparent liquid that meets specific quality standards, such as purity, color, moisture content and other indicators.

The production process of N-formylmorpholine is a complex chemical engineering process that requires precise control of reaction conditions and separation steps to ensure the quality of the product quality and yield. As technology develops, continuous process optimization and improvement are necessary to increase production efficiency and reduce environmental impact.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst

N-Formylmorpholine Safety Data Sheet

N-Formylmorpholine (N-Formylmorpholine), chemical formula C5H9NO, is a multifunctional organic compound widely used in chemical synthesis, Solvent and pharmaceutical industries. Due to its industrial importance, understanding its safety features is crucial to ensuring a safe workplace. The following is a summary of the N-Formylmorpholine Safety Data Sheet (SDS) based on general information covering its physical and chemical properties, health hazards, first aid measures, fire and explosion protection information, emergency release handling, handling and storage recommendations, and environmental protection measure.


1. Chemical identification

Product identification: N-formylmorpholine

Chemical name: N-Formylmorpholine

CAS number: [Fill in the actual CAS number here]

EINECS number: [Fill in the actual EINECS number here]

Molecular formula: C5H9NO

Molecular weight: about 101.13 g/mol

2. Risk Overview

Hazard Category:

  • Physical Hazards: Flammable liquids, vapors and air form explosive mixtures.
  • Health Hazards: May cause irritation and toxicity by inhalation, ingestion, or skin contact.
  • Environmental Hazard: Toxic to aquatic life.

Signal word: warning

Hazard Statement:

  • H225: Highly flammable liquid and vapor.
  • H315: Causes skin irritation.
  • H319: Causes serious eye irritation.
  • H335: May cause respiratory tract irritation.
  • H411: Toxic to aquatic life with long lasting effects.

Precautionary instructions:

  • P210: Keep away from heat, sparks, open flames and hot surfaces.
  • P261: Avoid breathing dust/fume/gas/mist/vapor/spray.
  • P273: Avoid release into the environment.
  • P305+P351+P338: If in eyes: Rinse carefully with water for several minutes. If you wear contact lenses and can easily remove them, remove them. Continue rinsing.

3. Composition/information components

  • Main ingredient: N-formylmorpholine
  • Purity/Concentration: [Fill in the actual purity/concentration here]
  • Other ingredients: [Fill in other additives or impurities here]

4. First aid measures

Inhalation:

  • Move to fresh air and keep breathing clear. If breathing is difficult, give oxygen. Seek medical attention.

Skin contact:

  • Take off contaminated clothing immediately and rinse skin with plenty of running water for at least 15 minutes. Seek medical attention.

Eye contact:

  • Immediately lift the eyelids and rinse thoroughly with running water or saline for 15 minutes. Seek medical attention.

Ingestion:

  • Do not induce vomiting. If swallowed, do not drink water unless directed by your doctor. Get medical attention immediately.

5. Firefighting measures

Fire-extinguishing media:

  • Use solvent-resistant foam, dry powder, or carbon dioxide to extinguish fires.

Special hazards:

  • Combustion produces toxic fumes, including carbon monoxide and nitrogen oxides.

6. Emergency leakage treatment

  • Wear appropriate personal protective equipment.
  • Isolate the leakage area and avoid direct contact.
  • Small spills: absorb with sand or other inert materials.
  • Substantial leakage: build dikes or dig pits to contain them.

7. Operation and storage

Operation precautions:

  • Operate in a well-ventilated area.
  • Avoid the generation of dust and vapors.
  • Use explosion-proof electrical equipment.

Storage Notes:

  • Store in a cool, dry and well-ventilated place.
  • Keep away from heat, sparks and open flames.
  • Store separately from oxidizing agents.

8. Exposure control/personal protection

Engineering Control:

  • Provide adequate local exhaust or general ventilation.

Respiratory protection:

  • Wear appropriate respiratory protective equipment when air pollutants exceed standards.

Eye protection:

  • Wear chemical safety glasses.

Body protection:

  • Wear protective clothing, gloves, and shoe covers.

9. Physical and chemical properties

  • Appearance and properties: Colorless to slightly yellow transparent liquid.
  • Melting point/freezing point: [Fill in actual melting point here]
  • Boiling point/boiling range: [Fill in actual boiling point here]
  • Flashpoint: [Fill in actual flashpoint here]
  • Explosion limit: [Fill in the actual explosion limit here]

10. Stability and reactivity

  • Avoid contact with strong oxidants, strong acids, and strong alkalis.

11. Toxicological information

  • Acute toxicity: LD50 (orally administered to mice) [fill in actual data here] mg/kg
  • Chronic toxicity: Long-term exposure may affect liver and kidney function.

12. Ecological information

  • Biodegradability: [Fill in actual data here]
  • Bioconcentration or bioaccumulation: [Fill in actual data here]

13. Disposal

  • Waste nature: [Fill in the actual waste nature here.??]
  • Waste disposal method: [Fill in the actual waste disposal method here]

14. Transportation information

  • United Nations number: [Fill in the actual UN number here]
  • Packaging category: [Fill in the actual packaging category here]

15. Regulatory information

  • Regulations: Comply with local and international chemical management regulations.

16. Other information

  • References: [List references here]

Please note that this SDS summary is based on general information. The actual safety data sheet should contain specific CAS number, EINECS number, purity , hazard classification and specific operating instructions. Always consult the complete safety data sheet and follow all applicable safety regulations before handling any chemical.

Extended reading:

Niax A-1Niax A-99

BDMAEE Manufacture

Toyocat NP catalyst Tosoh

Toyocat MR Gel balanced catalyst tetramethylhexamethylenediamine Tosoh

N-Acetylmorpholine

N-Ethylmorpholine

NT CAT 33LV

NT CAT ZF-10

DABCO MP608/Delayed equilibrium catalyst

TEDA-L33B/DABCO POLYCAT/Gel catalyst

16162636465340